April Seminar

src/archive/2026/2026-04-30.md

@@ -0,0 +1,65 @@
+# April - David C. Clarke
+
+!!! info "Event Details"
+
+    **Date/Time:**
+
+    Thursday, April 30th, 2026 :material-clock: 6:00pm - 8:00pm
+
+    **Location:**
+
+    :material-map-marker: **Location:** Vancouver General Hospital, Jimmy Pattison Pavilion North ([899 West 12th Ave., Vancouver, BC V5Z 1M9](https://maps.app.goo.gl/pvM16Frig5VjA9e69)), 141 TF
+
+/// html | div[class="bio"]
+
+![headshot](./images/david-clarke.jpg)
+
+/// html | div
+
+**Featured Speaker**: Dr. David C. Clarke
+
+**Talk Title:**  Towards manipulating how muscles grow: Bioinformatic inference of exercise-responsive control of RPS6KB1 expression
+
+<!---![type:video](https://www.youtube.com/embed/JcN11lVhwos)-->
+
+**Affiliation:**
+
+- Associate Professor, Biomedical Physiology and Kinesiology, Simon Fraser University
+
+///
+
+///
+
+**Bio:**
+
+Dr. Dave Clarke is Associate Professor in the Department of Biomedical Physiology and Kinesiology at Simon Fraser University in British Columbia, Canada. 
+
+Dr. Clarke holds BSc and MSc degrees in kinesiology and a PhD in chemical and biological engineering. 
+
+He directs the Laboratory for Quantitative Exercise Biology, the mission of which is to build predictive models of exercise-training adaptations to improve fundamental understanding and to optimize exercise training programs for health, fitness, rehabilitation or performance goals. To achieve this mission, the lab pursues three primary lines of inquiry: exercise-responsive cell signaling networks, training load quantification from wearable technology data, and evidence-based exercise programming.
+
+**Abstract:**
+
+Loss of skeletal muscle mass and function is a major challenge in aging. While mechanisms governing muscle mass have been experimentally described, frameworks are needed that integrate the data and inform the rational design of therapeutic strategies.
+
+Previous modeling studies demonstrated that the rate of muscle protein synthesis is particularly sensitive to the levels of p70 S6 kinase, a protein that governs translation. How its levels are determined is poorly understood. In this study, we applied a novel bioinformatic network inference algorithm called CARNIVAL (Causal Reasoning pipeline for Network identification using Integer VALue programming) to infer the molecular network governing the expression of the RPS6KB1 gene, which encodes p70 S6 kinase. 
+
+Our analysis revealed several candidate transcription factors that control RPS6KB1 expression in response to aerobic and resistance exercise. The CARNIVAL algorithm and those like it are powerful and generally applicable tools for inferring molecular networks from multi-omic data.
+
+---
+
+/// html | div[class="bio"]
+
+![headshot](./images/neera-patadia.jpeg)
+
+/// html | div
+
+**Trainee Speaker:** Neera Patadia
+
+**Affiliation:** Ph.D. Candidate in Bioinformatics, Pavlidis Lab, The University of British Columbia
+
+**Talk Title**: Examining Differential Expression Patterns in A Large Data Corpus
+
+///
+
+///

src/index.md

@@ -11,6 +11,6 @@ Visit our sister groups for bioinformatics events in Montreal ([MonBUG](https://
 ## VanBUG Monthly Event
 
 {%
-   include-markdown "./archive/2026/2026-02-19.md"
-   start="# Feb - Anne Condon"
+   include-markdown "./archive/2026/2026-04-30.md"
+   start="# April - David C. Clarke"
 %}

src/schedule.md

@@ -77,8 +77,8 @@
 
     :material-map-marker: **Location:** Vancouver General Hospital, Jimmy Pattison Pavilion North ([899 West 12th Ave., Vancouver, BC V5Z 1M9](https://maps.app.goo.gl/pvM16Frig5VjA9e69)), 141 TF
 
-    Featured Speaker: Dave Clark
+    Featured Speaker: David C. Clarke
 
-    Trainee Speaker: Nairuz Elazzabi
+    Trainee Speaker: Neera Patadia
 
 ///